Abstract

OPTIMIZATION & EVALUATION OF FAST- DISSOLVING TABLETS USING NATURAL AND SYNTHETIC SUPERDISINTEGRANTS

Rashmi Bagri*, Matam Namratha, Muthyala Apurva, Sri Chasmitha and Dr. G. Tulja Rani

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Abstract

A novel drug delivery method that offers the quickest onset of action and quick pharmacological effects after administration is the fastdissolving tablet. It can be taken without the need for water by just placing the tablets on the tongue. This medication delivery method works best in emergency scenarios where a quick medication response is required. Other excipients, as well as synthetic and natural superdisintegrants, are needed for the formulation of this type of dosage form. The pharmaceutical industry offers a range of artificial and natural Superdisintegrants can be found. In the current study, superdisintegrants are compared to determine which one releases drugs more quickly. The current study's objective was to create and evaluate a fast-dissolving tablet with both artificial and natural superdisintegrants. The fast-dissolving tablet was formulated using the direct compression technique. Pre- and post-compression parameters are assessed for the prepared tablets. According to the results, formulation batches F9 is the most preferred optimized batch. When drug release profiles were compared, the F9 batch—which contained combination of natural and synthetic superdisintegrants performed better than batches that contained only natural superdisintegrants. As a result, it was determined that combined natural and synthetic superdisintegrants perform better than alone natural ones.

Keywords: Superdisintegrants, Fenugreek mucilage powder, Crospovidone, Drug release, In-vitro dispersion time, Direct compression.