Abstract

NEW BIOMARKERS AS INDICATORS FOR SEPSIS IN FEBRILE LEUKAEMIC IRAQI PATIENTS

*Mohemid M Al-Jebouri and Ali M Hasen

Abstract

Background: Sepsis in leukaemic patients is a leading killer of both adult and pediatric patients. Analysis of cytokine levels measured around the onset of bactaeremia indicated that IL-8 followed by IL-6 are potentially useful for predicting gram-negative and gram positive bacteremia.Methodology: Interleukin-8(IL-8) and Interleukin-6 (IL-6) levels were estimated in 56 cases comprising; 21 bactaeremia by gramnegative bacterial infection ,15 bacteraemia by gram-positive cocci infection and 20 healthy controls.Results: The highest serum concentrations of IL-6 and IL-8 were observed in episodes of gramnegative bacteraemia and gram-positive bacteraemia but higher in former (98.7-95 pg/ml) by order. Conclusions: IL-8 and IL-6 can be used as sepsis biomarkers their and elevation in serum indicate bacteraemia specially by gram-negative bacteria and less by gram-positive bacteria.

Keywords: Leukaemia, Sepsis, Biomarkers, cytokines IL-6,IL-8.