Abstract

IN VITRO EVALUATION OF ANTIMICROBIAL ACTIVITY OF ENTOBAN SYRUP; A POLYHERBAL FORMULATION

Sadia Shakeel*, Khan Usmanghani, Zeeshan Ahmed Sheikh, Aqib Zahoor and Somia Gul

Abstract

The global dilemma of antimicrobial resistance is predominantly pressing in developing countries, where the infectious disease burden is high and cost constraints put off the appliance of expensive agents. Although there are splendid advancements in modern medicine, yet traditional medicine has always been accomplished for treating infections of gastrointestinal tract. A polyherbal formulation Entoban integrates an outstanding combination of Holarrhena antidysenterica, Berberis aristata, Symplocos racemosa, Querecus infectoria and Helicteres isora used for the treatment of acute gastrointestinal infections. Therefore the present study was directed to evaluate the invitro antimicrobial activity of polyherbal formulation against microorganism frequently involved in gastrointestinal infections. An antimicrobial activity was evaluated against five gram negative bacterial cultures namely Salmonella enteric, Eschericia coli, Shigella dysenteriae, Pseudomonas aeruginosa, Vibrio cholera and one gram positive bacterial culture Staphylococcus aureus by agar well diffusion method. The prepared syrup inhibited the growth of these organisms. Our findings suggest that, prepared polyherbal formulation have great potential against pathogenic microbes and can be used as antimicrobial agent for treatment of various infectious diseases of gastrointestinal tract.

Keywords: Antimicrobial, Entoban, herbal, gastrointestinal infections.