Abstract

TETRAHYDROPYRIMIDINES VIA THE BIGINELLI REACTION: SYNTHETIC STRATEGIES AND BIOLOGICAL ACTIVITIES

Apeksha K. Hegde and Suma B. V.*

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Abstract

Tetrahydropyrimidine nucleus has shown a significant rise in interest in the past few years which has been commonly synthesized through the well-known Biginelli’s one-pot synthesis. This review focuses on the timeline of Biginelli’s reaction, starting from the discovery to the strategies used to modify the nucleus to produce various derivatives, showing significant therapeutic activities like anti-microbial, antidiabetic, anti-inflammatory, anti-cancer, etc. The intrinsic mechanism followed, the expected intermediates in this one-pot synthesis, and the reaction conditions have also been discussed.

Keywords: Tetrahydropyrimidine, Biginelli, DHPM, antimicrobial, anti-diabetic, anti-inflammatory, anti-cancer.