Abstract

FORMULATION AND IN-VITRO EVALUATION OF RIZATRIPTAN BENZOATE SOLID LIPID NANOPARTICLES FOR THE TREATMENT OF EPILEPSY

Vipin Singh Yadav*, Dr. Shamim, Mrs. Muskan Bhardwaj

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Abstract

Epilepsy is one of the most common neurological disorders that affects people of all ages. The majority of people diagnosed with epilepsy may be alive Seizures-free life with appropriate antiepileptic drugs. In this context, this review provides up-to-date information on the various botanical ingredients that may: Treatment of different types of seizures via different signaling pathways in preclinical studies. The purpose of this review is to help you focus About the potential of anti-Epilepsy drugs and the pharmacology of various plant components Reasonable rationale for its use as an alternative treatment. The solid-lipid nanoparticles (SLNs) are a new class of nanocarriers which are based on the combined properties of fatty emulsion, liposomes and polymeric particles. The SLN comprises of the nanosized range spherical solid lipid particles. These lipid-based particles are capable of providing sustained release of their constituents and can exhibit targeted drug delivery if administered parenterally. The desired drug which is to be encapsulated into the nanostructured lipid carriers was firstly dispersed or dissolved either into the melted lipid which was solid at the room temperature or into the mix of an oil (liquid lipid) and a melted solid fatty. Then the resulting solid product was milled with the help of ball mill or mortar pestle up to the size of 50-100 micron. The product was characterized by X-ray diffraction (XRD). The polydispersity index and particle size of product obtained from the cold HPH technique are more as that of the hot HPH method.

Keywords: Epilepsy, Seizures, emulsion, lipids.