Abstract

DIFFERENT BIOLOGICAL ACTIVITIES AND STRUCTURE ACTIVITY STUDIES OF ACRIDINE AND ACRIDONE DERIVATIVES: AN UPDATED REVIEW

Sumit Nandi*, Sobhanjan Bhunia, Ishita Debnath, Shubhadeep Hazra, Suman Ghosh and Supriya Hazra

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Abstract

Acridine and its derivatives' diverse biological functions are thoroughly and up-to-date analyzed in this review, focusing on the structure-activity relationship (SAR) between them. The chemical properties of acridine and acridone are first discussed, emphasizing their distinct structural characteristics and possibilities for chemical modification. The improved biological activity of several substituted acridines, such as aminoacridine, hydroxyacridine, and chloroacridine, are investigated. The review explores the many biological actions of derivatives of acridine and acridone, with an emphasis on their antioxidant, antiviral, anticancer, and microbiological qualities. Acridine and acridone analogues that function as DNA-targeting drugs, telomerase inhibitors, protein kinase inhibitors, and topoisomerase inhibitors are of particular interest. This review also discussed the potential anticancer effects of acridone alkaloid derivatives, such acronycine and acronycine epoxide. The review also discusses the possible therapeutic use of acridine derivatives in the management of Alzheimer's disease. We go over the processes by which acridine derivatives work, providing some understanding of their possible applications as medicinal substances. This article also highlights the acridone compounds that show promise in defeating drug-resistant cancer cells due to their strong cytotoxic and antimultidrug resistance characteristics. This study attempts to provide a thorough grasp of the pharmacological potential of acridine and acridone derivatives by incorporating in-depth talks on the chemical nature, biological activities, along SAR of these compounds. Advances in the creation of acridine and acridone-based medicines are encouraged by this study, which is an invaluable resource for researchers as well as professionals in the disciplines of pharmacology and analytical chemistry.

Keywords: Anticancer, DNA-targeting drugs, Telomerase inhibitors, Protein kinase inhibitors, Topoisomerase inhibitors, Anti-multidrug resistance.