Abstract

EVALUATION OF ANTIDIARRHEAL ACTIVITY ON CORIANDRUM SATIVUM LINN., IN WISTAR ALBINO RATS

V.Nithya*

Abstract

Plants have been a valuable source of natural products for maintaining human health for many years. More recently, there has been a greater search for natural therapies. The use of herbal drugs in the treatment of diarrhea is a common practice in many countries. A range of medicinal plants with anti-diarrhoeal properties is widely used by traditional healers. The antidiarrhoeal effect of the aqueous extract of Coriandrum sativum Linn., leaves were investigated by employing four experimental models of diarrhea in wistar albino rats. Loperamide (3 mg/kg) was taken as standard, aqueous bulb extract of Coriandrum sativum150 & 300 mg/kg was used as a test doses. The water extract of Coriandrum sativum treated mice showed significant reduction in the faecal output and protected them from castor oil-induced diarrhoea. The extract tested at 150 and 300 mg/kg shown similar effect as that of standard drug (loperamide) by significantly inhibiting the frequency of defecation droppings compared to untreated control rats. Results obtained in this study substantiate the antidiarrheal effect of the aqueous extract of Coriandrum sativum L. leaves and its use by traditional practitioners in the treatment of diarrhoea.

Keywords: Castrol-induced diarrhea, Coriandrum sativum Linn., albino rats, Antidiarrhoeal activity.