Abstract

STYPTIC ACTIVITY OF SIDDHA POLY HERBAL FORMULATION SATHIKKAI PODI (SP) FOR MENORRHAGIA IN WISTAR ALBINO RATS

Anitha V.*, Aarthi G., Jayapriya R., Kamaraj A. and Anbu N.

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Abstract

Objective: The aim of the study was to explore the styptic activity of Siddha polyherbal formulation Sathikkai podi for menorrhagia in wistar albino rats. Methods: The Siddha polyherbal formulation Sathikkai podi indicated for Menorrhagia was prepared based on GMP (Good Clinical Practice) guidelines. Study procedure was approved by Institutional Animal Ethics Committee (IAEC). The experimental animals were measured for Clotting time (CT), Bleeding time (BT), Prothrombin time (PT), Activated partial thromboplastin time (APTT). And then, findings were compared with the standard drug. Results: The findings revealed that test drug Sathikkai podi at higher dosage 200 mg/kg (Group III) had equal effect on Styptic activity with percentage protection of 94.6% when compared with the standard drug Tranexamic acid about 40 mg/kg (Group IV) with percentage protection 94.6%. However, the test drug Sathikkai podi at a higher dosage 200 mg/kg (Group III) with a percentage protection 94.6% was highly effective when compared with lower dosage about 100 mg/kg (Group II) with a percentage protection 49.16%. Hence, the study resulted that the Siddha polyherbal formulation Sathikkai podi has an optimistic Styptic activity with more therapeutic value. Conclusion: The study concluded that the Siddha polyherbal formulation Sathikkai podi has a promising Styptic activity, probably due to the presence of biologically active phytocompounds. However, it is important to admit that there are some scientific evidences of the potential actions of these phytocompounds in Styptic activity.

Keywords: Siddha system, Sathikkai podi, Mennorrhagia, Styptic activity, Tranexamic acid, Wistar albino rats.