Abstract

ANTI-INFLAMMATORY ACTIVITY OF SIDDHA HERBOMINERAL FORMULATION AJAMOTHASTAKA MAATHIRAI ON CARRAGEENAN INDUCED PAW EDEMA IN WISTAR ALBINO RATS

Dr. Jayapriya R.*, Dr. Aarthi G., Dr. Anitha V., Dr. Kamaraj A. and Dr. N. Anbu

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Abstract

Objective: The aim of the study was to explore the anti-inflammatory activity of Siddha herbomineral formulation Ajamothastaka maathirai in albino rats, and compared with the standard drug Diclofenac. Methods: The Siddha herbomineral formulation Ajamothastaka maathirai indicated for Acid peptic disease was prepared based on GMP (Good Clinical Practice) guidelines. Study procedure was approved by Institutional Animal Ethics Committee (IAEC). The experimental animals were measured for paw edema volume at 1, 2, 3, 4, 5 h using Plethysmometer (Model PLM 01 PLUS UGO Basile, Italy. Edema was expressed as mean increase in paw volume relative to control animals. And then, findings were compared with drug Diclofenac (Standard drug). Results: The findings revealed that test drug Ajamothastaka maathirai at higher dosage 200 mg/kg (Group V) had equal effect on anti-inflammatory activity with percentage protection of 93.78% when compared with the standard drug Diclofenac at about 40 mg/kg (Group III) with percentage protection 97.41%. However, the test drug Ajamothastaka maathirai at a higher dosage 200 mg/kg (Group V) with a percentage protection 93.78% was highly effective when compared with lower dosage about 100 mg/kg (Group IV) with a percentage protection 28.36%. Hence, the study resulted that the Siddha herbomineral formulation Ajamothastaka maathirai has an optimistic anti-inflammatory activity with more therapeutic value. Conclusion: The study concluded that the Siddha herbomineral formulation Ajamothastaka maathirai has a promising anti-inflammatory activity, probably due to the presence of biologically active phytocompounds. However, it is important to admit that there are some scientific evidences of the potential actions of these phytocompounds in anti-inflammatory activity.

Keywords: Siddha system, Ajamothastaka maathirai, Acid peptic disease, Antiinflammatory activity, Diclofenac, Wistar albino rats.