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Abstract

RECENT ADVANCES IN TOPICAL NIOSOMAL DELIVERY FOR THE TREATMENT OF PSORIASIS

Sonia Tomar* and Anupama Kalia

Abstract

Psoriasis is renowned as a complex, chronic skin ailment that can have a significant impact on physical and mental health. It commonly causes red, scaly patches on the skin, even if some patients have no dermatological symptoms. Various drugs have been included in the treatment regimen of psoriasis which can be given orally as well as topically. However, the topical route for drug administration has advantages over the oral route as it avoids hepatic first pass effect, provides continuous drug delivery and improves patient compliance. In spite of many advantages, the lack of effective delivery of drug from existing topical systems has always been considered as the major limitation as low stratum corneum permeability limits the usefulness of topical drug delivery. This possibility of overcoming this barrier leads to emerging technology for development of drug-vesicular systems. The objective of vesicular system is to deliver the drug molecule to specific site without afflicting normal tissue. In comparison to conventional systems, these novel systems differ in their composition. The difference in composition influence the nature of self-assembled supra structure in terms of their shape, size, and surface properties. This leads to different class of carriers, viz. liposomes, niosomes, and transferosomes. Niosomes are formed from the self-assembly of non-ionic amphiphiles in combination with other lipid surfactants in aqueous medium. Niosomes have attracted a great deal of attention in the delivery of dermal drugs because of many advantages over the other vesicular systems, as they are biodegradable, non-toxic, amphiphilic in nature, penetration enhancers and effective in the modulation of drug release properties. The review focuses on available topical systems for the treatment of psoriasis and the effectiveness of niosomal topical delivery for the treatment of psoriasis.

Keywords: Niosomes, topical drug delivery, psoriasis, polymers, drug-vesicular systems.


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