Abstract

ANTIMICROBIAL SUSCEPTIBILITY PATTERNS OF STAPHYLOCOCCUS AUREUS TO DIFFERENT ANTIMICROBIAL AGENTS ISOLATED AS CLINICAL SAMPLES AT CERTAIN GENERAL HOSPITALS IN SANA'A CITY, YEMEN

Abdul Basit Ahmed Al Ghoury, Mokhtar Abd-hafiz Al-Ghorafi, Mahmoud Mahyoob Alburyhi* and Maged Alwan Noman

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Abstract

Background: Staphylococcus aureus has become an important cause of persistent nosocomial and community acquired infections by worldwide spread of Methicillin Resistant Staphylococcus aureus (MRSA) in the modern day. Objective: The study aims to assess the antibiotic susceptibility pattern of S. aureus from different hospitals clinical specimens and determining prevalence of MRSA. Methods: A retrospective cross-sectional study of 500 samples S. aureus isolates from clinical samples of patients admitted to Al-Gumhury Hospital, 48 Model Hospital, Al-Thawra General Hospital, and National Center of Public Health Laboratories (NCPHL) in Sana'a city. Kirby-Bauer disk diffusion, antimicrobial susceptibility testing (AST), is used. Results: The results revealed that the proportion of S. aureus infection, 334 (66.8%) were males and 166 (33.2%) were females. Moreover, Al- Thawra General Hospital had 198 (39.6%) S. aureus isolates, then (NCPHL) 112 (22.4%), Al-Gumhouri Teaching Hospital 109 (21.8%) and 48 Model Hospital 81 (16.2%). A statistically significant association between hospitals and MRSA was found. MRSA strains were predominantly isolated from pus and ear swab 32.4% and 24% respectively. Moreover, the prevalence of MRSA among all S. aureus isolates was (20.8 %). In addition, a certain antimicrobial such as Linezolid, Vancomycin, Clindamycin and Amikacin had the highest sensitivity rate. Conversely, Penicillin, Methicillin, Oxacillin, Cefoxitin, and others showed the highest resistance rates. Conclusions: The study reveals a moderate prevalence of MRSA representing nearly quarter of S. aureus cases at certain general hospitals in Sana'a city, Yemen, indicates ongoing screening and follow-up programs and suggestions for the development of antimicrobial stewardship programs in Sana'a, Yemen.

Keywords: Antimicrobial susceptibility patterns, S. aureus, MRSA, Yemen.