Abstract

ADVANCES IN ANALYTICAL TECHNIQUES FOR VILDAGLIPTIN: A COMPREHENSIVE REVIEW

Srivani Mallepelli*, T. Yashwanth and T. Rama Rao

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Abstract

The review article discusses vildagliptin, an antihyperglycemic medication targeting dipeptidyl peptidase-4 (DPP-4) to manage type 2 diabetes mellitus. This drug enhances pancreatic alpha- and beta-cell activity, improving glycaemic control as indicated by glycated haemoglobin and fasting plasma glucose (FPG) levels. Chemically identified as (s)-1-[(3-Hydroxy-1-adamantyl) glycyl] pyrrolidine-2- carbonitrile, vildagliptin's quantification in pharmaceutical formulations (tablets) and bulk is crucial. The review focuses on various analytical methods—UV spectroscopy, reversed phase high performance liquid chromatography (RP-HPLC), high performance liquid chromatography (HPLC), high performance thin layer chromatography (HPTLC), and ultra performance liquid chromatography (UPLC)—used to analyze vildagliptin alone or in combination forms, compiling recent advancements in analytical techniques.

Keywords: Vildagliptin, UV spectroscopy, reversed phase high performance liquid chromatography (RP-HPLC), High performance thin layer chromatography (HPTLC) and Ultra performance liquid chromatography (UPLC).