Abstract

ORODISPERSIBLE TABLETS: AN ACCLAIMED NOVEL INNOVATIVE DRUG DELIVERY SYSTEMS AND EMERGING MARKET PROSPECTS

K. M. Manjanna and Mounika C.*

Abstract

In recent scenario, certain novel medicinal products need to the patients for right time for the treatment of therapy either oral or peroral route of administration. Among all route of administration the oral delivery is well known preferred delivery system for systemic administration of therapeutic agents because of accurate dosage, lowcost therapy, self-medication, non-invasive method and ease of administration leading to high level of patient compliance. Orodispersible tablets (ODTs) are the novel dosage form which quickly disintegrates in the mouth (1-3 min) without chewing upon oral administration and without the need of water. ODTs are very credence dosage form to administered peroral route especially in pediatric, geriatric and nomadic patients which is difficult to swallowing in emergency period of treatment. Various scientists have formulated ODTs by following various techniques such as compression, molding, melt granulation, phase-transition process, sublimation, freeze-drying, spray-drying, and effervescent process. Present outline observed in the pharmaceutical technology many number of scientists have explored several poorly water soluble drugs with various superdisintegrates in the form ODTs to improve solubility and bioavailability. The present review has been expressing the details fast and present challenges of ODTs during the formulation, manufacturing techniques and evaluation factors to improving oral bioavailability of lipophillic drugs.

Keywords: Disintegration, manufacturing techniques, Orodispersible tablets, Superdisintegrants.