Abstract

A CROSS SECTIONAL STUDY ON PREVALENCE OF VITAMIN B-12 DEFICIENCY IN PATIENTS WITH DIABETES ON LONG TERM TREATMENT WITH METFORMIN

Kothwal Zabeen*, Dr. Swapna Moparthi, Dr. Sowjanya Kondru, Dr. Mohammed Misbah Ul Haq, Prashansa Kapoor, Mohammadakil Shaikh, Dr. Fizia Mohammadi, Dr. Srinivasarao Varagani, Morziul Haque and Habeeb Rahman Khan

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Abstract

Introduction: Vitamin B12 insufficiency is linked to metformin, a major medicine used to manage diabetes, and this may have long-term health implications. The purpose of this study is to determine the prevalence of vitamin B12 deficiency in diabetic patients on long-term metformin therapy, as well as to assess the factors that contribute to this deficiency. Methodology: 90 diabetic individuals who had been taking metformin for more than 1 year were participated in a crosssectional study. Following measurement, the levels of vitamin B12 were classified as insufficient, borderline, or sufficient. We gathered and examined information on age, gender, length of therapy and the prevalence of vitamin B12 deficiency in diabetic patients. Results: 44.44% of people have a vitamin B12 deficiency. Higher frequencies of deficiency were substantially correlated with older ages and longer metformin medication durations. Conclusion: In conclusion, the research shows that long-term metformin users, especially those who are older and have been on medication for a longer period of time, have a high prevalence of vitamin B12 deficiency. To enhance patient care, routine vitamin B12 testing and management are advised.

Keywords: Vitamin B12 deficiency, metformin therapy, diabetes management, prevalence, long-term treatment.