Abstract

ANTI-INFLAMMATORY ACTIVITY OF SIDDHA POLYHERBAL FORMULATION MOOLANOI CHOORANAM ON CARRAGEENAN INDUCED PAW EDEMA IN WISTAR ALBINO RATS

Dr. Aarthi G.*, Dr. Jayapriya R., Dr. Anitha V. and Dr. Kamaraj A.

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Abstract

Objective: The aim of the study was to explore the anti-inflammatory activity of Siddha Polyherbal formulation Moolanoichooranam in albino rats, and compared with the standard drug Diclofenac. Methods: The Siddha Polyherbal formulation Moolanoichooranam indicated for Internal haemorrhoids was prepared based on GMP (Good Clinical Practice) guidelines. Study procedure was approved by Institutional Animal Ethics Committee (IAEC). The experimental animals were measured for paw edema volume at 1, 2, 3, 4, 5 h using Plethysmometer (Model 7150 UGO Basile, Italy. Edema was expressed as mean increase in paw volume relative to control animals. And then, findings were compared with drug Diclofenac (Standard drug). Results: The findings revealed that test drug Moolanoichooranam higher dosage 200 mg/kg (Group V) had more or less equal effect on anti-inflammatory activity with percentage protection of 65.43% when compared with the standard drug Diclofenac at about 40 mg/kg (Group III) with percentage protection 86.68%. However, the test drug Moolanoichooranam a higher dosage 200 mg/kg (Group V) with a percentage protection 65.43% was highly effective when compared with lower dosage about 100 mg/kg (Group IV) with a percentage protection 31.39%. Hence, the study resulted that the Siddha Polyherbal formulation Moolanoichooranam has an optimistic anti-inflammatory activity with more therapeutic value. Conclusion: The study concluded that the Siddha Polyherbal formulation Moolanoichooranam has a promising anti-inflammatory activity, probably due to the presence of biologically active phytocompounds. However, it is important to admit that there are some scientific evidences of the potential actions of these phytocompounds in antiinflammatory activity.

Keywords: Siddha system, Moolanoichooranam, Internal Haemorrhoids, Antiinflammatory activity, Diclofenac, Wistar albino rats.