Abstract

FORMULATION AND EVALUATION OF CELECOXIB EMULGEL FOR TOPICAL DRUG DELIVERY

Aman Kumar, Anchal Rana, Jasbir Kumar, Mayank Bhardwaj, Neha Sharma* and Naresh Singh Gill

Abstract

Osteoarthritis (OA) is the most common form of arthritis and is caused by degeneration of the joint cartilage and growth of new bone, cartilage and connective tissue. Celecoxib is a selected COX-2 inhibitor which is used as a nonsteroidal anti-inflammatory drug (NSAID) which has analgesic and antipyretic activity. It is one of the most potent nonsteroidal anti-inflammatory agents. Celecoxib belongs to BCS class II drug with its bioavailability being limited by the poor aqueous solubility. Emulgel is the promising drug delivery system for the delivery of hydrophobic drugs. Preparation of emulgel is done by incorporation method. percentage drug entrapment was found was 88.86±0.2, zeta potential -25.8mV. The emulgel showed 92.11±0.55 release after 24 hours in a controlled manner. The outcome of work recognized a unique, simple, and stable product having improved drug entrapment and increased bioavailability thus improved bioavailability at osteoarthritis disease with less adverse actions.

Keywords: Osteoarthritis (OA), Celecoxib, Emulgel, NSAIDS, bioavailability.