Abstract

FORMULATION AND EVALUATION OF LIQUORICE EMULGEL FOR TOPICAL DRUG DELIVERY

Anchal Rana, Aman Kumar, Anmol Rana, Neha Sharma*, Kanupriya Chaudhary and Naresh Singh Gill

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Abstract

Acne vulgaris, commonly called acne, is a skin condition affecting many individuals globally. The multifactorial onset of acne vulgaris manifests as pilosebaceous follicles. Open and closed comedones, as well as inflammatory lesions like papules, are indicative of this condition nodules and pustules. Phytoconstituents present in methanolic extracts of Camellia sinensis, Glycyrrhiza glabra and Calendula officinalis (COME) have antibacterial and antioxidant properties. Extracts loaded with carbopol® 934 were used for the preparation of herbal (F1-F8) and polyherbal gel (PHF), followed by evaluation for pH, viscosity, spreadability and in vitro drug release and FT-IR spectral analysis. Emulgel is the promising drug delivery system for the delivery of hydrophobic drugs. Preparation of emulgel is done by incorporation method. Higuchi's approach was followed by the optimized formulation, F3, which demonstrated a 93% drug release. The outcome demonstrated that the liquorice extract was homogeneous when placed into an oil-in-water emulsion, and the in vitro release analysis indicates that the F3 formulation exhibits the highest level of drug release. The conclusion that licorice extract of emulgel can be employed as an efficient topical dose form is that it combines the benefits of an emulsion and gel.

Keywords: Acne vulgaris, Glycyrrhiza glabra, COME, PHF, Emulgel.