Abstract

DEVELOPMENT AND CHARACTERIZATION OF TRETINOIN NANOSPONGE GEL FOR SKIN DELIVERY

*Simranjeet Kaur, Supneet Kaur and Dr. Naresh Singh Gill

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Abstract

The aim of this research work is to formulate and characterization of tretinoin nanosponge gel for skin delivery. The primary goal of this study was to increase the residence time, bioavailability and onset of action. Acne vulgaris is one of the most common dermatological disorders that effect people in their adolescence. Acne vulgaris are simply known as acne is a human skin disease characterized by skin with scaly red skin, blackheads, whiteheads. Tretinoin block several important inflammatory pathways that activated in acne all like receptors, leukocytes migration AP-1 pathway. It improves scarring texture and fades pigmentation. Nanosponge gel has large and tremendous effector potential to serve as topical drug delivery systems, better antifungal activity, storage and stability. Nanosponges are water soluble; its particle mix with water and use it as transport fluid. Preparation of nanosponge is done by emulsion solvent diffusion method. percentage drug entrapment was found was 99.9±0.01. particle size of 404.6nm, 28.2%, zeta potential -21.6mV. The nanosponge gel showed 85.69±0.003 release after 24 hours in a controlled manner. The outcome of work recognized a unique, simple, and stable product having improved drug entrapment and increased bioavailability thus improved bioavailability at acne vulgaris disease with less adverse actions.

Keywords: Nanosponge, Tretinoin, topical drug delivery, gels.