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Abstract

BUCCAL DRUG DELIVERY SYSTEM: A REVIEW

Avani J. Ramani*, Dr. Kanu R. Patel and Dr. Mukesh R. Patel

Abstract

Mucoadhesion can be defined as a state in which two components, of which one is of biological origin are held together for extended periods of time by the help of interfacial forces. Mucoadhesive are synthetic or natural polymer, which interact with the mucus.layer covering the mucosal epithelial surface, and mucin molecules constituting a major part of mucus. The concept of mucoadhesive as alters many investigator to the possibility that this polymer can be used over come physiological barrier in long-term drug delivery. Buccal mucosa is the preferred site for both systemic and local drug action. The mucosa has a rich blood supply and it relatively permeable. The buccal region of the oral cavity is an attractive target for administration of the drug of choice, particularly in overcoming deficiencies associated with the latter mode of administration. Problems such as high first-pass metabolism and drug degradation in the gastrointestinal environment can be circumvented by administering the drug via the buccal route. Moreover, rapid onset of action can be achieved relative to the oral route and the formulation can be removed if therapy is required to be discontinued. It is also possible to administer drugs to patients who unconscious and less cooperative. In buccal drug delivery systems mucoadhesion is the key element so various mucoadhesive polymers have been utilized in different dosages form. Various bioadhesive dosages form such as Chewing gum, tablets, Patches, Hydrogel, Thiolated tablets are discussed in this review article.

Keywords: Buccal drug delivery, Bioadhesive polymers, Buccal Mucosa, permeation enhancers.


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