Abstract

FORMULATION AND QUALITY CONTROL OF ORALLY DISINTEGRATING TABLETS (ODTS): RECENT ADVANCES AND PERSPECTIVES

Mamillapalli Lakshman Kumar*, Karnati Jothi Shree, Narne Mounika, Tirumani Akhila, Nelakurthi Manju Bhargavi and Brahmaiah Bonthagarala

Abstract

The 1980s saw the introduction of ODT technologies' products to the market, which have since seen a steady increase in demand and a quick expansion of their product streams. Without the need for water, oral disintegrating tablets (ODTs) dissolve or quickly disintegrate in the oral cavity. In both academia and the pharmaceutical business, there is a growing demand for ODTs. ODTs are said to provide a number of benefits over other traditional tablets. When saliva travels down into the stomach, some of them are absorbed from the mouth, throat, and esophagus, which significantly increase the drug's bioavailability. In addition, ODTs' instantaneous release characteristic makes them a well-liked oral dose form for kids, adults, and patients who require a quick start of action. The characteristics of the excipients and active substances utilized in the formulation of ODTs are described in the current review paper. This gives solutions for issues related to ODTs and addresses several ODT formulation and preparation methods, each having pros and cons. additionally, necessary concerns and quality control procedures are provided.

Keywords: Oral Disintegrating Tablets (ODTs), Quickly Disintegration, Oral cavity, Instantaneous Release.