Abstract

KAPOSI SARCOMA –A MOLECULAR OUTLOOK

Pramod Singh Khatri* and Surinder Kumar Yadav

Abstract

Kaposi’s sarcoma–associated herpes virus (KSHV) [or human herpes virus 8 (HHV-8)] is the most successive reason for threat among AIDS patients. KSHV and related herpes viruses have widely pilfered cellular cDNAs from the host genome, giving a unique chance to investigate the scope of viral mechanisms for controlling cell proliferation. A large portion of the viral regulatory homologs encode proteins that straightforwardly repress host adaptive and innate immunity. Other viral proteins focuses retinoblastoma protein and p53 control of tumor suppressor pathways, which additionally assume key effector roles in intracellular immune reactions. The immune evasion strategies utilized by KSHV, by focusing on tumor suppressor pathways actuated amid immune system signaling, may prompt coincidental cell proliferation and tumorigenesis in susceptible hosts.

Keywords: KSHV, HHV-8, antiviral immunity, tumor virus, viral oncogenes.