Abstract

IN VITRO AND IN VIVO ANTI HEPATOTOXIC EVALUATION OF ALPINIA GALANGA ON D- GALACTOSAMINE INDUCED TOXICITY

Srividya Ammayappan Rajam*, Sameer Kumar Varma, Vishnuvarthan Vaithiyalingam Jagannathan

Abstract

Alpinia galangal is a rhizome belongs to the family Zingeberaceae. Qualitative phytochemical analysis of plant extracts showed the presence of majority of the compound including terpenoids, flavonoids, alkaloids, tannins, saponins and glycosides. The hydro alcoholic hot extract has shown high total phenol content 14.50 ± 0.210 mg/g and hydro alcoholic cold shown 12.59 ± 0.295 mg/g. Alpinia galangal hydro alcoholic extract prepared by hot maceration showed potent antioxidant activity with IC value 7.7 ± 0.121 μg/ml. The antihepatotoxicity produced by the extract at concentration of 200 and 400 μg/ml was effective against the D- Galactosamine induced hepatotoxicity, whereas at the concentration of 600 and 800 μg/ml it was found to be cytotoxic for both the hydro alcoholic extracts prepared by cold and hot maceration process. A significant increase in the levels of ASAT, ALAT, ALP, total Bilirubin, direct Bilirubin (P

Keywords: Alpinia galangal, anti hepatoxicity, antioxidant, cytotoxic.