Abstract

PROTECTIVE EFFECTS OF TURMERIC AGAINST CISPLATIN INDUCED GENOTOXICITY ON BONE MARROW CELLS OF MICE

Anuradha Somisetty* and Rudrama Devi Kanapuram

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Abstract

The inorganic platinum compound cisplatin (CP), has been used as a cancer therapy for decades and exhibits strong anti-tumor activity. However, the wide application of Cisplatin is largely limited due to its side effects. Natural therapies, such as the use of plant-derived products in cancer treatment, may reduce adverse side effects. In the present investigation studied the possible anti genotoxicity effects of Turmeric ethanolic extract on chromosomal aberrations induced by Cisplatin in the bone marrow cells of mice. The results indicate that Turmeric extract decreased significantly the percentage of chromosomal aberrations induced by Cisplatin in a dose dependent manner indicates the anti genotoxic effects of Turmeric. Hence Turmeric can be used as chemopreventive regimen.

Keywords: Cisplatin, Turmeric, Antigenotoxicity, Chromosomal Abberations, Bone Marrow.