Abstract

EFFECT OF ANTIULCER ACTIVITY OF RAUWOLFIA SERPENTINE (ROOT)

Kuldip Dhangar*, Dr. C. K. Tyagi, Dr. Narendra Patel and Dr. Sujata Kushwaha

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Abstract

Peptic ulcer disease has been one of the most prevalent gastrointestinal tract disorders in clinical practice for more than a century. Because it affects a large number of individuals worldwide, some researchers believe that Peptic ulcer disease is the new plague of the twenty-first century. Though a variety of medications are already available for treatment, recent discoveries have highlighted the complex pathophysiology of peptic ulcers. However, a significant disadvantage of gastric ulcer therapy nowadays is that the majority of medications on the market have a poor track record of treating stomach disorders and can have toxic side effects or even change the body's biochemical processes when used repeatedly. The current study aims to assess the gastroprotective benefits of Rauvolfia serpentina methanolic root extract against rats that have stomach ulcers induced by Indomethacin. Despite a great deal of research on ulcers, the exact reason of persistent peptic ulceration remains unknown. It is commonly acknowledged that ulcers arise from an imbalance between aggressive factors and the preservation of mucosal integrity through endogenous defense systems, even if the genesis of the ulcers is unknown in most cases. Plant extracts are among the various medicinal substances used to restore equilibrium. One such herbal medication that is presently being studied for its potential to treat ulcers is Rauvolfia serpentina root extract.

Keywords: Rauvolfia serpentina, Peptic ulcer, Gastroprotective effects.