Abstract

EVALUATION OF ANTI-HYPERLIPIDEMIC ACTIVITY OF LEAVES EXTRACT OF AEGLE GLUTINOSA PLANT

Imran Ahmad*, Dr. Narendra Patel, Dr. C. K. Tyagi and Firoz Khan

Abstract

The present study was designed to perform preliminary phytochemical screening, acute oral toxicity and to evaluate antihyperglycemic activity of hydroalcoholic extract of Aegle Glutinosa Plant. Hypercholesterolaemia is the state been illustrate by an increased fatty substances called lipids, rise in plasma TCs and TGs levels it is as well called hyper lipoproteinemia. Aegle Glutinosa whole plant was extracted using ethanol ans water mixute as solvent by cold maceration Process. The extract was subjected to preliminary phytochemical screening. Acute oral toxicity studies were performed to determine dose test. Preliminary phytochemical screening revealed the presence of alkaloids, carbohydrates, glycosides, saponins, tannins, flavonoids, Triterpenes. The evaluation of antihyperlipidemic activity was done using High Fat Diet induced hyperlipidemia models in Wistar albino rats. for 15 Days, and then they are checked for the blood parameter levels like TC, TGs, LDL, VLDL, and HDL. Hydroalcoholic extracts at low dose (250 mg/kg) and high dose (500 mg/kg) significantly at high doses it reduced the levels of TC, TGL, LDL, VLDL & increased the levels of HDL and reduced the body weights.

Keywords: Aegle Glutinosa Plant, Hypercholesterolaemia, HDL, LDL, VLDL, SGOT, SGPT.