Abstract

AN OBSERVATIONAL STUDY ON EFFECTIVENESS OF MONOTHERAPY AND COMBINATION THERAPY OF ANALGESICS AND NSAIDS IN POST-OPERATIVE PAIN

Dr. Jane Nisha Soans*, Dr. Freny Mathew Shiju, Dr. Niharika S. Shetty, Dr. Sukanya Edagottu

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Abstract

The study focuses on the effectiveness of monotherapy and combination therapy of analgesics and NSAIDs (non-steroidal antiinflammatory drugs) in managing post-operative pain. Multimodal analgesia is an effective approach for managing postoperative pain, with various combinations including acetaminophen, NSAIDs, opioids like tramadol, and intravenous medications like aceclofenac and diclofenac. These strategies result in enhanced pain management, reduced opioid use, increased patient satisfaction, faster recovery, fewer adverse effects, and lower healthcare expenses. Data was collected using the WONG-BAKER FACIAL GRIMACE scale, and descriptive statistical analysis and chi-square tests were performed. Results showed that most patients had the highest administration of twice-daily dosing (91%), followed by a shorter administration of once-daily dosing (9%). The majority of patients had a hospital stay duration of 1-3 days (76%), followed by 4-6 days (69%), 7-9 days (2%), and 10–12 days (1%). The usage pattern and effectiveness were predominantly high in the combination therapy of paracetamol and aceclofenac/diclofenac (39.33%), followed by paracetamol (22.66%), paracetamol and tramadol (21.33%), aceclofenac/diclofenac (9.33%), and tramadol (7.33%). In conclusion, the combination therapy of analgesics and NSAIDs has high rates of efficacy in managing post-operative pain compared to monotherapy of analgesics or NSAIDs. This combination provides a well-tolerated and effective means of analgesia for moderate-tosevere pain and can be used as an alternative or adjunct to opioid use post-surgery. Balanced analgesia with a combination of NSAIDS and analgesics forms the preferred method postoperatively in major surgical procedures.

Keywords: NSAIDs, Safety, Efficacy, Post-operative pain, Multimodal analgesia, Balanced Analgesia.