Abstract

ANTI-INFLAMMATORY AND WOUND HEALING ACTIVITY OF PHYLLANTHUS FRATERNUS WEBSTER

Deepika Sharma*, Bhanu P. S. Sagar and Amrita Singh

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Abstract

Herbal medicines have become widely sought-after in developing nations as a preferred choice for basic healthcare needs. Phyllanthus fraternus Webster, commonly referred as Gulf Leaf-Flower, is an annual herb which falls under the Euphorbiaceae family, is cultivated in tropical regions across the globe, including nations such as China, Malaysia, Indonesia, Pakistan, Sri Lanka, and various regions of India. In India, it can be found in states like Uttar Pradesh, Bihar, Gujarat, Maharashtra, Kerala, and West Bengal, and it is particularly prevalent in the entire Northeastern part of the country, especially in Assam, Arunachal Pradesh, and Manipur. So, present investigation was an attempt to investigate pharmacological potential of Phyllanthus fraternus Webster. Phytochemical evaluation was performed on EEPFL which indicates that the plant contains alkaloid, tannins, saponins, terpenoids, flavonoids and steroids. TPC and TFC estimation analysis revealed that amount of TPC and TFC found in Phyllanthus fraternus was 44.44 ± 6.42 mg GAE/g FW and 0.511 mg QE/g FW respectively. The plant has great antioxidant potential and showed a great anti- inflammatory agent. EEPFL 200mg and 400mg showed significant stabilization towards RRBC. In the experimental models of carrageenan induced rat paw edema, effects of EEPFL at a dose of 200mg/kg and 400mg/kg showed a significant inhibition when compared with controls. The study results showed that EEPFL is a potent wound healer. On 10th day of post wound creation, it was observed that percentage of wound contraction was 100% in rats which were treated with EEPFL 400mg/kg.

Keywords: Anti-Inflammatory, Antioxidant, Total Phenolic Content, Total Flavonoid Content, Macroscopic, Microscopic, Wound Healing, Phytochemical.