Abstract

ALPHA GLUCOSIDASE INHIBITORY ACTIVITY OF SIDDHA FORMULATION SEENTHIL CHOORANAM-IN VITRO STUDY

J. Rohini alias Elavarasi*, S. Jani Antony, R. Murugalakshmi and R. Menaka

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Abstract

According to the World Health Organization (WHO), Diabetes Mellitus (DM) is one of the top ten morbid conditions, characterized by high blood sugar level, or hyperglycemia. Type 2 diabetes is the most common type of diabetes. Inhibition of α-glucosidase enzyme is an effective method of managing diabetes.This study assess the α- glucosidase inhibitory activity of seenthil chooranam (SC), a siddha formulation practised by siddha physicians in the management of type 2 diabetes mellitus. SC is regarded as an effective medicine for reducing blood sugar level.The alpha glucosidase inhibitory activity of SC is determined using spectrophotometric assay technique.SC exhibits α-glucosidase inhibitory activity (IC 50 = 380.8 ± 104.5μg/ml).

Keywords: Diabetes mellitus, Seenthil chooranam, Madhumegam, In-vitro Alpha-glucosidase inhibition activity, ancient medicine, Siddha.