Abstract

STUDY OF INCONGRUENT UPSHOT OF ERYTHROCYTE & ITS RELEVANCES

Om Bagade?, Poonam Mane, Rani Dhole, Jyoti Gholave and Poonam Pote

Abstract

Erythrocytes are the Red Blood Cells, color is due to the heme group of hemoglobin. The size of erythrocytes varies widely among vertebrate species. The development of RBC takes place in bone marrow. Life span is approximately 120 days, Erythropoiesis is the development of erythrocytes. The membrane perturbation, electroencapsulation, hypo osmotic lysis, lipid fusion endocytosis, these are the ways for the drug loading in erythrocytes. Drug content, osmotic fragility, osmotic shock, turbulence shock and in-vitro drug release are the evaluation parameter for it. These methods are effective for insertion of low molecular weight drug but it has very less % entrapment efficiency. These drug loaded erythrocytes having large number of biological and biomedical applications. The concept of employing erythrocytes as drug or bioactive carrier could surely find the cancer’s cure. Genetic engineering aspects can be coupled to give a newer dimension to the existing cellular drug carrier concept that one can reached to the better drug delivery to get maximum effective concentration i.e more quantity of bioavailable drug in the blood to get desire biological activity.

Keywords: Oxyhemoglobin, Electroencapsulation, Hypoosmotic.