Abstract

MARESINS: THE PRODIGAL DOYENNE OF THE RESOLUTION REALM

Dr. Sathyasree M.*, Dr. Jaishree Tukaram Kshirsagar, Dr. Shyam Sharma K., Dr. Monika A. and Dr. Nithiyaraj S.

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Abstract

Inflammation plays a crucial role in protecting the human body from harmful external antigens and microorganisms. Nevertheless, an exaggerated inflammatory response can lead to tissue damage and interfere with organ functions. Hence, it is imperative to understand anti-inflammatory processes and resolution mechanisms. A controlled and dynamic process known as "resolution of inflammation" helps the body regain equilibrium by removing cell debris from the injured tissue. Specialized pro-resolving mediators (SPMs), endogenous bioactive lipids such as lipoxins (LXs), resolvins (Rvs), protectins (PDs), and maresins (MaRs) are responsible for coordinating this physiological response. Macrophages, in particular, produce maresins (MaRs), which have tissue-regenerating, pro-resolving, and antiinflammatory qualities. The underlying molecular processes of maresin in periodontitis have been the subject of an expanding body of clinical and experimental studies. MaRs has recently shown a direct correlation with the periodontal disease's ability to reduce inflammation.

Keywords: Periodontitis, macrophage, maresins, inflammation, resolution, Specialized pro-resolving mediators (SPMs).