Abstract

AN OVERVIEW OF THE EFFLUX PUMP IN MICROBIAL IN THE DIFFERENT STAGES

Prof. Rahul Pawar*, Prof. Garje B. H., Prof. Dongare R. C., Mrs. Khedkar U. D.,

Abstract

Bacterial efflux pumps (EPs) are proteins located and embedded in the bacterial plasma membrane whose function is to penetrate the organism's protective cell wall and reach the periplasm or cytoplasm before reaching its intended target. Recognize and eliminate pollutants.[1] In addition, EP also recognizes toxic compounds that are bacterial metabolites and are responsible for their excretion function. In other words, EP is a transporter of harmful compounds from within the bacterial cell to the external environment. With the possible exception of an excretory function, EPs utilize energy sources for their function in terms of transporting compounds against concentration gradients. Efflux pumps are generally composed of outer membrane proteins, intermediate periplasmic proteins, inner membrane proteins, and transmembrane tubules.[2] Transmembrane passages are located in the outer membrane of the cell. The duct also binds to two of her other proteins. Periplasmic membrane proteins and integral membrane transporters. Periplasmic and inner membrane proteins of the system combine to control the opening and closing of ducts. When a toxin binds to this inner membrane protein, it triggers a biochemical cascade that transmits signals to periplasmic and outer membrane proteins to open channels and transport the toxin out of the cell. This mechanism relies on energy-dependent protein-protein interactions generated by toxin translocation to H+ ions via inner membrane transporters.[3]

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