Abstract

DEVELOPMENT AND EVALUATION OF SWELLABLE CONTROLLED POROSITY OSMOTIC PUMP TABLETS OF METOPROLOL SUCCINATE AND RAMIPRIL

Padma priya S¹ , Ravichandran V¹,Suba V²

¹Vels college of pharmacy, Velan nagar, Pallavaram, Chennai-600 117, Tamilnadu, India.
²National Institute of siddha,Tambaram sanitorium,Chennai 600047, Tamilnadu, India.

Abstract

Swellable controlled porosity osmotic pump (SEOP) utilizes the osmotic pressure and polymer-swelling force to deliver drugs to the GI tract in a reliable and reproducible manner. Metoprolol and ramipril are one of the combinations indicated in the management of hypertension in patients with heart failure and post myocardial infarction. This combination was selected to develop SEOP to release the drugs continuously for a period of 24hrs and the release is controlled by swellable polymer and the osmogen.SCPOP tablets of Metoprolol and Ramipril were prepared using additives like Mannitol MCC, talc, magnesium stearate , aerosol with varying concentrations of osmopolymers(PEO,Carbopol and PVAand SCMC) coating of cellulose acetate as semi permeable membrane ,Dibutyl phthalate as plasticizer. An orifice was made on one face of the tablet mechanically. Effects of different concentrations of PEO (MRSC1-MRSC3) carbopol (MRSC4-MRSC6) PVAand SCMC(MRSC7-MRSC9) on the in vitro release were studied. On comparing in vitro release of formulations (MRSC1-MRSC6), the release rate decreased with the increased concentrations of polymers The decreased release rate was due to due to solubilitymodulating properties of the polymers. Among the formulations, MRSC7 shown optimum drug release rate 99.98%and 92.32% for metoprolol and ramipril respectively at the end of 24 hours. The optimized formulation was independent of the agitation intensity, pH of the medium, stable and delivers Metoprolol and Ramipril at a zero order rate for 24 hrs.

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