Abstract

PHARMACEUTICAL SCIENCES FABRICATION AND TESTING OF THE NOVEL ARDUINO BASED BIO-ADHESIVITY TEST APPARATUS DESIGNED FOR TRANSDERMAL PRODUCTS

Shivani*, Nishant Thakur, Bhupinder Kaur, Chandan Sharma and Manish Goswami

Abstract

Objective: The aim of this study is to design an apparatus for measuring the bio-adhesivity of adhesive pharmaceutical formulations. Materials and Methods: The study utilized an Arduino Uno based microcontroller, a 40 Kg stress sensor, customized steel chassis, Natural gums and Dura Tak grade adhesives. Adhesion capacity of the adhesives was evaluated using a developed apparatus, comparing it to the manual force needed to overcome the adhesivity.[1] Variables including the force and the amount of work the adhesives do record by the microcontroller were key focuses of the research. Results: The force required for detachment varied between sodium alginate (2.5 kg) and DURA TAK 87-235 2.5% solution. Adhesion strength in pressuresensitive adhesives is influenced by cross-linking and tack force.[2] The maximum standard deviation in the study ±1.67 was experienced with Sodium alginate 50% solution while leas standard deviation ±0.56 with Dura TaK-87-6908-2.5 % solution. The highest variation in the case of Sodium Alginate was attributed to its swelling index and sensitivity towards the temperature. Conclusion: The results obtained using the developed apparatus were reliable, demonstrating that the instrument is cost-effective and user-friendly in a laboratory setting.

Keywords: Bio-adhesivity, Adhesive formulations, Arduino Uno, Stress sensor, Sodium alginate, Dura Tak, Pressure-sensitive adhesives, Adhesion strength, Laboratory apparatus.