Abstract

CHOLESTEROL, BIOMARKERS AND CANCER THERAPY

Pratibha Kamble*, Sameer Kulkarni, Matadeen Mishra and Dayanand A.Bhiwgade

Abstract

Background: Cytotoxic agents contributes an remarkable therapautic features and has a fundamental importance in current cancer chemotherapy. The therapy focuses mainly on minimizing cytotoxicity and therapautic potential of these drugs is dependent on cellular status. Results: Rats administered with 0.4 mg/kg bodywt ip cisplatin daily for 8 weeks showed significant increase in Liver cholesterol content compared to control group however, etoposide therapy at 1mg/kg bodywt ip daily for 8 weeks to rats showed significant decrease in liver cholesterol levels. The cisplatin and etoposide treated kidney showed significant decrease compared to control rats. Antineoplastic agent adriamycin at 1mg/kg bodywt to rats ip, three doses per week and total of 12 doses showed significant changes in body weight and organ weight. The biomarkers of kidney γ-glutamyl transpeptidase (GGT), drug-metabolizing enzyme Cytochrome p450 & b5 and Lipid peroxidation (MDA content) showed significant decrease compared to control counterpart. However, Glutathione-S-Transferase (GST) activity showed significant increase compared to control rats. Conclusion: We hypothesize that at given dose Cisplatin and Etoposide can inhibit the cholesterol synthesis and might control an increase in tumor cell growth. Additionly, an increase in GST and decrease in GGT significant biomarker's of kidney can represent the extent of oxidative stress on the organ.

Keywords: Biomarkers, GGT, GST, Cholesterol, Adriamycin, Cisplatin, Etoposide.