Abstract

INVESTIGATING THERAPEUTIC POTENTIAL: P2X7 RECEPTOR ANTAGONISTS IN COMBATING CHRONIC COMPLICATIONS

Bipin Singh*, Vishal Kajla, Neha Bala, Raveena Jassal, Muskaan, Mohd. Sayam, Shikha Kalyan

Abstract

P2X7 receptor antagonists are substances that block the P2X7 receptor's function. The P2X7 receptor is a purinergic receptor that is mostly present in immune cells. These antagonists’s ability to control inflammatory reactions and cell death pathways linked to a number of illnesses has drawn attention to them. The term "disease management" describes tacties. intended to reduce symptoms, impede the spread of the illness, and enhance overall patient outcomes. P2X7 receptor antagonists and disease management are related because of their capacity to target important pathways connected to inflammatory conditions like cancer, neurological diseases, and autoimmune disorders. When used in conjunction with current treatments, these antagonists have demonstrated promise in lowering inflammation, avoiding tissue damage, and improving therapeutic efficacy by blocking P2X7 receptor activation. Moreover, recent studies indicate that P2X7 receptor antagonists may be used to treat conditions other than classic inflammatory ones, such as pain management, mental health issues, and metabolic illnesses. P2X7 receptor antagonists have a great deal of promise for personalized medicine in the future, as they allow targeted therapy to be customized to the unique profiles of individual patients. Finally, the investigation of P2X7 receptor antagonists as therapeutic agents offers a strong path forward for the development of disease management approaches, bringing to patients across a range of medical illnesses the prospect of better treatment outcomes and a higher standard of living.

Keywords: P2X7 receptor antagonist, disease management, inflammation, therapeutic potential, personalized medicine.