Abstract

ANALYSIS OF HEAVY METAL, AFLATOXIN, PESTICIDE RESIDUE, MICROBIAL CONTAMINATION AND PHYTOCHEMICAL ANALYSIS OF SIDDHA HERBAL DRUG KANDUPARANGI VER CHOORANAM (KVC)

Dr. Muthu Krishnan D.*, Dr. Manjuhemamalini N., Dr. Shanmugapriya C. and Dr. Satheeshkumar A.

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Abstract

Aim: The aim of the study was to evaluate the presence of Heavy metal, Aflatoxin, Pesiticide residue and Microbial contamination of Siddha herbal formulation Kanduparangi ver Chooranam (KVC). Place of study: Heavy metal analysis, Aflatoxin assay, Pesiticide residue, Microbial contamination analysis and phytochemical evaluation were conducted at Noble Research Solutions, Kolathur, Chennai -99. Methodology: The Siddha formulation Kanduparangi ver Chooranam was prepared as per Good Manufacturing Practices (GMP) guidelines and the Heavy metal analysis, Aflatoxin assay, Pesiticide residue, Microbial contamination analysis and phytochemical evaluation were conducted at Noble Research Solutions, Kolathur, Chennai -99. Results: The results of Heavy metal analysis of Kanduparangi ver Chooranam (KVC) shown the presence of Lead at 2.017 PPM and Arsenic, Cadmium, Mercury at Below Detection Limit (BDL). Aflatoxin assay of KVC shown the absence of Aflatoxin B1, Aflatoxin B2, Aflatoxin G1, Aflatoxin G2. Pesticide residue analysis showed that there were no traces of Pesticide residues such as Organo chlorine, Organo phosphorus, Organo carbamates and Pyrethroids. In Microbial contamination analysis, Test for Specific Pathogen shown the absence of Organisms E-coli, Salmonella, Staphylococcus Aureus, Pseudomonas Aeruginosa and No Bacterial and fungal growth or colonies were observed in the Sterility test of KVC as per the methods of AYUSH specifications. The Phytochemical screening of KVC shown the presence of Alkaloids, Carbohydrates, Saponins, Flavanoids, Diterpenes, Gum and Mucilage. Conclusion: From the results, it is concluded that the study medicine KVC has Heavy metal content below the permissible limit as per PLIM guidelines of AYUSH, and the sample were free from Aflatoxins, Pesiticides, Microbes and Specific Pathogens and it shown the compendious understanding of presence of Phytochemical components which ensures that the study medicine Kanduparangi ver Chooranam was safe therapeutically.

Keywords: Kanduparangi ver Chooranam, Siddha, Sinusitis, Heavy metal, Aflatoxins, pesticide, phytochemicals.