Abstract

PHARMACOLOGICAL EVALUATION OF ANTIDEPRESSANT POTENTIAL OF KAEMPFEROL IN ALLOXAN INDUCED DIABETIC RAT

Charushila P. Bhintade*, Dr. Hemant Kamble, Ghodke S. R., Gaikwad Ashlesha S.

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Abstract

This study aims to evaluate the pharmacological effects of Kaempferol on alloxan-induced diabetic rats. A total of 36 male Sprague Dawley rats will be used, divided into six groups: normal control, diabetes control, and four treatment groups receiving Kaempferol at different doses (25, 50, and 100 mg/kg) or Fluoxetine (10 mg/kg) for 6 weeks. Parameters to be evaluated include body weight, food and water intake, urine output, fasting blood glucose level, and behavioral tests such as elevated plus maze and forced swim test. Ex-vivo parameters including oxidative stress markers and brain GABA levels will also be assessed. The study aims to determine the antidepressant activity of Kaempferol in diabetic rats and provide insights into its potential therapeutic applications.

Keywords: Kaempferol, Alloxan, Diabetes, Fluoxetine.