Abstract

A PROSPECTIVE OBSERVATIONAL STUDY ON DRUG UTILIZATION EVALUATION AND POTENTIAL DRUG-DRUG INTERACTION OF ANALGESIC DRUGS IN AN ORTHOPAEDIC OUTPATIENT DEPARTMENT AT TERTIARY CARE HOSPITAL

Dhruviben Patel*, Dhruvi Parmar, Dhrupalben Patel, Nidhiben Rao, Dharmendra Singh Rajput

Abstract

Objective: Primary Objective: To evaluate prescribing pattern of analgesic drugs in orthopedic outpatient department. Secondary Objective: To study the potential drug-drug interaction of prescribed drugs to the patient. Methodology: A prospective observational study was conducted after the approval of the iec of CHARUSAT. The study was conducted at IRIS Hospital, Anand, Gujarat. Participants were selected for the inclusion and exclusion criteria and those who follow the inclusion criteria were include in the study. All the details of the participant were filled in the Case Report Form (CRF) by the investigator. Result: A total of 450 prescriptions were analyzed, of which 41% and 59% precipitation were of males and females respectively. Age wise distributions of the patients were analyzed. Total 495 numbers of analgesic prescribed, it was observed that combination analgesic & monotherapy prescribed was 78% and 22% respectively. However, very few of the drugs were prescribed in generic name (4%). Most commonly hypertension (43.87%) comorbidity were observed. Our result found that the primary complaint of orthopaedic patients was knee osteoarthritis (OA). Most commonly analgesic prescribed in tablet (67%) formulation. Prescription were analyzed based on severity total 59% of the moderate potential DDI was observed. Conclusion: The study investigated the prescribing pattern and potential Drug – Drug Interaction (DDI) of analgesics in orthopedic OPD (outpatient department) to observed, evaluate & suggested modification to improve the prescribing habits of the healthcare provider.

Keywords: Prescribing Pattern, Inappropriate Drug Use, Drug interaction, WHO Prescribing Indicator.