Abstract

FORMULATION AND EVALUATION OF ANTIDANDRUFF HAIR GEL FOR TREATMENT OF SEBORRHOEIC DERMATITIS

S.P. Dhamane*, N.V. Tayade, V.V. Potnis, A.S. Kulkarni and A.S. Gadekar

Abstract

Seborrhoeic dermatitis is a chronic, non inflammatory condition of the scalp that is characterized by excessive scaling of scalp tissue. Dandruff may be a symptom of more serious problem, such as scalp become thick or yellowish colour seborrheic dermatitis. Various Antifungal agents are widely used in hair shampoos for the treatment of dandruff. These products show temporary effect for span of hours in a day on the scalp. Therefore, an attempt has been made for formulation of Fluconazole and Tea tree oil anti-dandruff gel which may give antidandruff action for number of hours. Placebo formulations were prepared by using different concentrations of carbopol 940, glycerine as a humectant and allantoin as a anti-irritant. All formulations were evaluated for physical appearance, pH, viscosity, extrudability, spradability. Based on viscosity, spreadability, extrudability formulation CGA8 containing 0.6% carbopol 940, glycerine and allantoin was selected as best formulation for addition of fluconazole and tea tree oil. The formulation FTCGA8 (containing 2% Fluconazole and 5% Tea tree oil) and TCGA8 (containing 5% Tea tree oil) shows good drug release than FCGA8 as it contains 2% fluconazole only. Antifungal activity shows that formulation FTCGA8 and TCGA8 shows higher efficacy.

Keywords: Fluconazole, Tea tree oil, Seborrhoeic dermatitis hair gel, Malassezia furfur (MTCC-1374).