Abstract

A COMPARATIVE OBSERVATIONAL STUDY BETWEEN DEXMEDETOMIDINE AND FENTANYL TO MITIGATE THE INTUBATION RESPONSE IN GYNAECOLOGICAL RELATEDOPERATIONS

Adiraju Lakshmi Shravani*, Akula Pavani, R. Arjun Sngh, Dr. A. V. Kishore Babu and Dr. A. Srinivasa Rao

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Abstract

Anesthesia involves the controlled, temporary loss of sensation or consciousness, primarily for medical procedures. It encompasses analgesia, paralysis, amnesia, and unconsciousness. Intubation, specifically tracheal intubation, is a procedure that involves inserting a tube into the trachea to maintain an open airway or administer medication. This procedure can trigger an "intubation response," a reflex sympathetic reaction causing an increase in heart rate, pulse, and blood pressure due to a surge in catecholamines. This study aimed to compare the efficacy of Dexmedetomidine (0.5 mcg/kg) and Fentanyl (1.5 mcg/kg) in attenuating the hemodynamic response during intubation in patients undergoing gynecological surgeries. Secondary objectives included evaluating changes in heart rate, blood pressure, oxygen saturation, and respiratory rate. The study, conducted over six months at Medicover Women and Child Hospital in Hyderabad, included 40 patients. Data were collected on heart rate, blood pressure, oxygen saturation, and respiratory rate before and after intubation. Results showed that both Dexmedetomidine and Fentanyl were effective in reducing the hemodynamic response to intubation. However, Dexmedetomidine was found to be superior to Fentanyl in attenuating this response. Thus, Dexmedetomidine 0.5 mcg/kg is recommended over Fentanyl 1.5 mcg/kg for managing hemodynamic changes during laryngoscopy and intubation.

Keywords: Intubation, Mitigate, Dexmedetomidine, Fentanyl.