Abstract

CHEWABLE SOFT GELATIN CAPSULES: A REVIEW OF MANUFACTURING TECHONOLOGY

V. Praveenkumar*, R. Kumaravelrajan and S. Sathyanarayanan

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Abstract

This study aims to create and assess chewable soft gelatin capsules, designed as a user-friendly dosage form that facilitates administration, particularly for pediatric and geriatric patients. Traditionally, soft gelatin capsules are utilized to deliver liquid or semi-solid active pharmaceutical ingredients (APIs) within a gelatin shell. This research, however, concentrates on a chewable version that aims to enhance adherence among individuals who experience difficulties with swallowing. In this formulation, the gelatin shell is modified to ensure easy chewing while preserving the stability and bioavailability of the active ingredients contained within. A variety of excipients, such as plasticizers and sweeteners, are optimized to provide an enjoyable taste and texture, while also ensuring the capsules maintain their structural integrity. The evaluation of these capsules includes assessments of their mechanical properties, disintegration time, taste-masking effectiveness, and the release profile of the active ingredients.

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