Abstract

REVIEW ON FORMULATION AND EVALUATION OF SOLID LIPID NANOPARTICLES

T. Raja, A.R. Mohammed Aseef, K.S. Mohamed Rafeek, D. Ragul, E. Naresh and M. Sujitha*

Abstract

Significance Solid lipid nanoparticles (SLN) are a novel drug delivery system that has attracted increasing interest and have been used to deliver many types of drugs since their introduction in the 1990s. SLNs have been paid attention in the field because of its special properties such as good bio-compatibility, controlled releasing and more stable. The abstract briefly covers areas of the SLN formulation, focusing on factors such as lipid composition, surfactants and approaches used for the preparation influencing particle size, drug loading etc. We summarize the influence of these parameters on the pharmacokinetics and therapeutic potential of SLN-incorporated drugs. The review also discusses the different techniques used for characterizing SLNs in relation to their function as one of the quality tests imposed on this type of product symbols use script. To sum up, this review will help to accumulate the current state-of-art regarding SLNs on how they will be attained or manufactured along with its characterization and perspective uses in pharmaceutical research. A literature review of existing research serves as a primary resource for investigators and clinicians looking to negotiate the complex reality of SLN-based drug delivery systems. A meticulous review of this paper will certainly benefit the scientists engaged in SLN-based drug delivery systems.

Keywords: Solid lipid nanoparticles, Methods of preparation, Evaluation, Route of administration, Application.