Abstract

FABRICATION AND EVALUATION OF COSTUS PICTUS HERBAL TABLET

Niranjan Ravur* Ravela Navya Durga, Sampathkumar.R, and Radhika Parasuram Rajan

Abstract

In spite of all the advances in therapeutics, diabetes still remains as a major cause of morbidity and mortality in the world. Herbal formulations are becoming popular nowadays particularly in the treatment of diabetes. Curative properties in the Medicinal plants are due to the presence of various complex chemical substance of different composition, which are found as secondary plant metabolites in one or more parts of the plants. Formulation and evaluation of anti-diabetic activity of herbal tablets were prepared from the leaves extract of the plant Costus pictus. Herbal tablet was formulated using a dry plant extract of Costus pictus, with varied concentration of binder polyvinyl pyrolidone K30 and with various excipients as, aerosil, micro crystalline cellulose and magnesium stearate. The tablets were prepared by direct compression method. The results of physicochemical parameters and precompression studies revealed that all the values were within the acceptable limit. The evaluation of formulated tablets as weight variation, friability, hardness, disintegration time and in-vitro drug release were performed. All the evaluation of the formulated tablets were found to be within the pharmacopoeial limits. The optimized formulation F4 were subjected for anti-diabetic effect in wistar albino rabbits for 14 days and effect on blood glucose levels were studied. The stability studies were conducted for 45 days and found to be stable.

Keywords: Costus pictus, pyrolidone, variation, friability, hardness, disintegration.