Abstract

A COMPREHENSIVE REVIEW OF PHYTOMOLECULES USED IN THE TREATMENT OF SKIN DISEASES

S. A. Vadivel*, Dr. S. Anbazhagan, R. Prasanth, B. N. Jayaprakash, P. Jegadeeswari and G. Asha

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Abstract

Background: Skin diseases are prevalent and diverse, presenting significant challenges in dermatological care. The utilization of plantderived compounds, or phytomolecules, has long been a cornerstone in traditional medicine for treating various skin disorders. Recent research has validated many of these traditional uses, highlighting the therapeutic potential of phytomolecules in modern dermatology. Objective: This review aims to provide a comprehensive overview of key phytomolecules used in the treatment of skin diseases. It focuses on their mechanisms of action, clinical efficacy, and relevance in contemporary dermatological practices. Methods: A thorough literature review was conducted to identify and summarize the role of major phytomolecules, including alkaloids, flavonoids, tannins, terpenoids, saponins, phenolic acids, and essential oils, in the management of skin diseases. Relevant studies, clinical trials, and traditional applications were analyzed to elucidate their therapeutic benefits. Results: The review highlights several phytomolecules with notable antiinflammatory, antimicrobial, antioxidant, and wound-healing properties. Key compounds such as berberine, quercetin, ellagic acid, limonene, glycyrrhizin, salicylic acid, and tea tree oil have demonstrated efficacy in treating conditions such as acne, psoriasis, eczema, and rosacea. These compounds offer diverse mechanisms of action, from reducing inflammation and combating infections to enhancing skin regeneration and protecting against oxidative stress. Conclusion: Phytomolecules represent a valuable resource for dermatological therapy, offering natural alternatives to conventional treatments. Their historical use in traditional medicine, combined with modern scientific validation, underscores their significance in managing skin diseases. Continued research is essential to further understand their mechanisms and integrate these natural compounds into effective treatment strategies.

Keywords: Phytomolecules, skin diseases, dermatology, anti-inflammatory, antimicrobial, antioxidants, wound healing.