Abstract

A REVIEW OF ANALYTICAL METHODS FOR ESTIMATION OF VINCA ALKALOIDS FROM CATHARANTHUS ROSEUS

*Zainab Kasam Ansari and Mazahvancheril Meera Devi

.

Abstract

Catharanthus roseus, also known as Madagascar Periwinkle is a pretty ornamental plant of Vinca rosea (C. roseus), is a member of the Apocynaceae family. Cancer, one of the leading illness, and public health burden in developed and developing country. A phytochemical investigation of the plant has demonstrated that a number of alkaloidal substances can be obtained with antitumor activity. Among the numerous natural products, acting via different mechanisms of action, microtubule-targeting agents (MTAs) have a high therapeutic potential, since they disrupt the abnormal cancer cell growth, interfering with the continuous mitotic division. Vinca alkaloids are the earliest developed MTAs. There major vinca alkaloids in clinical use are vincristine (VCR), vinblastine (VBL), vinorelbine (VRL), and vindesine (VDS) and vinflunine. The present review is about the various analytical techniques employed for the estimation of Vinca alkaloids.

Keywords: Analytical techniques, validation, High performance liquid chromatography, Ultra-high performance liquid chromatography, High performance thin layer chromatography.