Abstract

POLYSACCHARIDE-BASED DRUG DELIVERY SYSTEMS IN CANCER THERAPY: A COMPREHENSIVE REVIEW OF APPLICATIONS AND ADVANCES

Akash P. Patil*, Nikhil M. Yadav, Prasannjeet S. Bhopale, Chetan M. Patil,

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Abstract

Tumor therapy is a growing research topic due to the increasing global frequency of tumor. Challenges include antitumour medicines' organisation lethality, lack of tumor localization, and diffusion throughout the entire body. Anti tumor drugs have short half-lives in circulation of blood and unsatisfactory cinacalcet characteristics. Amalgamation of low molecular mass pharmaceuticals to supermolecule transporters has been utilized to improve drug distribution. Various supermolecule, comprising proteins, antibodies, polysaccharides, lectins, and synthetic polymers, have been linked with antitumour medicines. tumor is defined by the unrestrained proliferation of aberrant cells, that can infect adjacent tissues and spread to other parts of the body via metastases. Currently, tumor cure techniques include surgery, radiation, and chemotherapy. Chemotherapy is required for organisation sic cure of metastases associated with tumour development. Organisations based on polysaccharides have received increased interest due to their low cost, abundance, exceptional. Physicochemical and biological characteristics, along with the straightforwardness of the chemical reactions needed for particular modifications. Polysaccharides are useful as drug transporters due to their steadiness, non-lethality, and biodegradability.

Keywords: Chitosan, PTX, Curcumin, Alginate, Pectin Cisplatin.