Abstract

IV BOLUS RANITIDINE INDUCED ANAPHYLAXIS REACTION WITH TRIGGERED THROMBOCYTOPENIA: A CASE STUDY

Kingsley Joshua I.*, Aswathee Sivakumar, Moushmi Arulmoorthy, Sengottuvelu Singaravel and Sivakumar Thangavel

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Abstract

Introduction: Ranitidine is an H2 receptor antagonist used to heal stomach ulcers; however, its administration rarely leads to anaphylaxis eruption. Most of the drugs can cause serious allergic reactions that will rapidly develop skin rash symptoms initially which then affects the respiratory and circulatory obstructions which is known to be anaphylactic shock. Case Report: A 65 year old female patient was diagnosed with acute febrile illness and thrombocytopenia and had complaints of fever, vomiting and headache. Intravenous fluids were given to the patient and when administering the drug Ranitidine through bolus injection, the patient felt itching, and dyspnea, had a decreased pulse rate, and within minutes patient was unconscious which is considered to be anaphylactic. Immediately patient was shifted to the Intensive Care Unit and treatment was given but the patient did not show any improvement. Discussion: Ranitidine-induced Anaphylaxis was diagnosed based on the early reaction and the skin test with positive results. IgE-mediated is the assumed natural reaction. The relation of the issue with the patient's preexisting thrombocytopenia is one of the causes of the worsening of the reaction. Specific examples in medical literature favor the suggestion that there is a certain degree of crossreactivity between H2 receptor antagonists and different allergic reactions. Conclusion: This case report exhibits the rarity and seriousness of the emergence of Ranitidine-induced Anaphylaxis thus obliging the necessity of devising proper diagnostic tools, care, and constant monitoring of patients alongside the promotion of new drugs to bring down the level of such risks.

Keywords: Anaphylactic Reaction, Ranitidine, Adverse reaction.