Abstract

FORMULATION AND EVALUATION OF ORALLY DISINTEGRATING PELLETS

Sanika N. Mate*, Poonam M. Padole and Dr. Ravikiran B. Wakade

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Abstract

The main aim of the present study was to evaluate the potential of orally disintegrating pellets (ODPs) as an approach for taste masking of Mebendazole using ion exchange resin. The drug resin complex was prepared in batch method with complexation of drug with resin. Maximum drug loading capacity of resins Kyron T-134 was calculated then Drug Resin Complexes were optimized by effect of drug resin ratio. Pellets were prepared by extrusion/spheronization with kyron T- 134, Kyron T-314, sucrose, corn starch, sucralose, Vaniline flavor, and 1% PVP solution. The prepared pellets were characterized for percentage yield, drug content, particle size, in vitro drug release & in vitro disintegration. The obtained ODPs disintegrate in less than 20 s. So, conclusion, states that ODPs can be utilized as an alternative option for effective taste masking and rapid disintegration in the oral cavity.

Keywords: Pellets, orally disintegrating, Kyron, Drug- resin complex.