Abstract

TADALAFIL’S ROLE IN TESTICULAR REGENERATION: ANTIINFLAMMATORY AND ANTIOXIDANT EFFECTS POST HEAT STRESS

Hadeel Hassan Mohieldien Fadlelmawla*, Dr. K. Jesindha Beyatricks, Dr. N. Sriharsha

.

Abstract

Background and objectives: An effective phosphodiesterase inhibitor 5 (PDE-5) is tadalafil, which is frequently prescribed to treat erectile dysfunction. Its therapeutic potential, however, goes beyond this particular indication. This study looked at how tadalafil affected male Wistar rats' testicular parenchyma's ability to heal heat stress in the testicles. After undergoing testicular heat stress, 54 Wistar rats were randomised to receive either tadalafil therapy (TAD) or no treatment at all (control). Two different doses of TAD were given intraperitoneally: 0.9 mg/kg and 1.8 mg/kg. On days 7, 15, and 30 following heat shock, biometric parameters, testicular histopathology assessment, serum testosterone levels, oxidative stress, and interleukin levels were assessed.[1] PDE5 inhibitors are indicated as therapy for benign prostatic hyperplasia with lower urinary tract symptoms, pulmonary arterial hypertension and erectile dysfunction, and have also been shown to have an anti-inflammatory effect against tissue inflammation.[2] At the conclusion of each experimental period, the animals were put to sleep, and samples were taken up until day seven following the injury, TAD therapy preserved testicular weight and slowed the testicular degeneration process. On the other hand, serum testosterone levels were still lowered in the groups that received treatment on days 7 and 15 following heat stress. At varying doses, TAD also reduced TNF-α and NO levels, but had no effect on IL-6. Even though TNF-α and NO levels were systematically reduced, the use of TAD following heat shock showed anti-inflammatory and antioxidant capabilities; nonetheless, it did not stop the exacerbation of testicular lesions in subsequent periods.[1] Because of this, the resumption of the spermatogenic process may be compromised because this specific PDE-5 inhibitor, at the dosages utilised, did not positively affect testosterone levels throughout the postthermal stress phase.[1]

Keywords: Tadalafil, testicular, wistar rats.