Abstract

ACUTE ORAL TOXICITY STUDY OF SHIGRUPUNARNAVADI YOGA – A UNIQUE POLY-HERBAL FORMULATION

Arundhathi Prasad*, Ravikrishna S., Sudhakar Bhat and Chaithra Hebbar

.

Abstract

Shigrupunarnavadi yoga has been extensively used for decades as a lepa (external application) among Keraliya visha vaidyas (Traditional practicers of Kerala) to treat Vishaja Shopha (swelling due to toxin). Despite of its effectiveness as an external application, there have been no studies conducted to assess its potency when administered internally as a kwatha (decoction). Therefore, this study aims to evaluate the acute oral toxicity of Shigrupunarnavadi Kwatha according to Organisation for Economic Co-operation and Development 425 Guidelines, ensuring its safety for clinical use. During the acute toxicity studies (over 72hrs), no clinical signs of toxicity or mortality were observed in any of the wistar strain albino rats at different dose levels tested (50 mg to 2000 mg/kg body weight). Considering the outcome, it was inferred that Shigrupunarnavadi Kwatha is safe and non-toxic for internal administration.

Keywords: Shigrupunarnavadi yoga, Kwatha, Vishaja shopha, Acute oral toxicity.